Reversing Endothelial Injury – BionicOldGuy

Age-Associated Injury to Endothelium

The endothelium is the innermost layer of blood vessels, which may change into broken as we become old, an vital side of heart problems. I found the very important position of the endothelium once I found that I’ve hypertension if it isn’t managed by metoprolol (a drugs I’m on to forestall coronary heart arrhythmias, which had been a aspect impact of my needing a coronary heart valve alternative). The blood strain incident and what I subsequently realized from it’s mentioned right here. My most vital takeaway was to ensure I’ve a number of nitrates in my weight loss plan, from meals like beets and arugula. That has been working properly for retaining blood strain regular. However that’s serving to to maintain my blood vessels dilating usually, regardless of age-related harm to the endothelium. As I discussed on the finish of that earlier submit, I’d prefer to find out about scale back harm to the endothelium.

It seems that is doable, and that is mentioned within the newest video on Dr. Greger’s nutritionfacts web site. The hot button is the position of endothelial progenitor cells, which assist with the well being of the endothelium. Within the video a captivating examine is described that demonstrates this. Peripheral artery illness is a kind of heart problems the impacts blood vessels just like the legs, in an identical method to how the coronary arteries are broken in coronary artery illness. The blood vessels might be so badly broken that victims are severely restricted in train capability, like solely with the ability to stroll for a minute or much less. As well as, necessity for amputation is usually a main consequence of peripheral artery illness. The researchers cut up individuals into a bunch that acquired bone marrow transplants, and a management group that acquired solely an injection of their very own blood. The group with bone marrow transplants had considerably improved train time, versus no enchancment within the management. Additionally, within the management group, throughout follow-up over the next months, 14% required amputations over the next months versus none within the handled group. The improved arterial perform within the handled group is said to enhanced impact of endothelial progenitor cells [2].

So Dr. Greger now examined how can we enhance endothelial progenitor cells by way of life means. Two very important components should not smoking (and avoiding publicity to secondhand smoke), and train. For weight loss plan, vital components are decreasing saturated fats consumption, consuming a whole-food plant-based weight loss plan, and particularly consuming berries, onions, and ingesting inexperienced tea. I’m already checking all of the bins on this listing besides the final two, so I intend to spice up onion consumption and take a look at inexperienced tea. The endothelium of my arteries in all probability already seems just like the “60+” within the image above. It’s thrilling to assume it’s doable to reverse this and have successfully youthful arteries.


  1. Sharma, S, et al, “Randomized, Double-Blind, Placebo-Managed Trial to Consider Security and Therapeutic Efficacy of Angiogenesis Induced by Intraarterial Autologous Bone Marrow–Derived Stem Cells in Sufferers with Extreme Peripheral Arterial Illness”, Journal of Vascular and Interventional Radiology, 2021. on-line right here
  2. Teraa, M, et al, “Impact of repetitive intra-arterial infusion of bone marrow mononuclear cells in sufferers with no-option limb ischemia: the randomized, double-blind, placebo-controlled Rejuvenating Endothelial Progenitor Cells through Transcutaneous Intra-arterial Supplementation”, Circulation, 2015. on-line right here.

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